贵州医科大学学报

2011, v.36;No.149(02) 158-161

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中药复方JEYS解痉镇痛抗炎作用的实验研究
Experimental Studies on Spasmolysis,Analgesia and Anti-inflammatory Effects of Traditional Chinese Medicine Compound JEYS

胡勇;李淑芳;刘迪成;
HU Yong1,LI Shufang1,LIU Dicheng2(1.Department of Pharmacology,Guiyang Medical College,Guiyang 550004,Guizhou,China;2.Department of Physiology,Guiyang Medical College,Guiyang 550004,Guizhou,China)

摘要(Abstract):

目的:观察中药复方JEYS的解痉镇痛抗炎作用。方法:用乙酰胆碱(Ach)和氯化钡(BaCl2)致家兔离体胆囊平滑肌收缩,观察TCCJEYS的解痉作用;采用冰醋酸致小鼠扭体法观察TCCJEYS的镇痛作用,采用二甲苯致小鼠耳廓肿胀法观察TCCJEYS的抗炎作用。结果:TCCJEYS能抑制Ach和BaCl2引起的家兔胆囊平滑肌收缩,延长小鼠的扭体潜伏期和减少小鼠的扭体次数;减轻小鼠的耳廓肿胀度,并对耳廓肿胀具有明显的抑制率。结论:TCCJEYS具有解痉镇痛抗炎的作用。
Objective: To observe the spasmolysis,analgesia and anti-inflammatory effects of traditional chinese medicine compound JEYS(TCCJEYS).Methods: Contraction of smooth muscle of rabbit ex vivo gallbladder was evocated by acetylcholine(Ach) and barium chloride(BaCl2),and the smooth muscle was then treated with TCCJEYS of different dosages to show TCCJEYS's spasmolytic effects;Ice acetic acid test was performed to observe the analgesic effect.Model mice with auricle tumefaction caused by xylene were treated with TCCJEYS to show its anti-inflammatory effect.Results: TCCJEYS inhibited the contraction of gallbladder smooth muscle,prolonged the delitescence of body twist,reduced body twist frequency,lessened ear swelling,and showed obviously inhibitory effect on ear swelling.Conclusions: TCCJEYS has obvious effects of spasmolysis,analgesia and anti-inflammatory.

关键词(KeyWords): 复方(中药);胆囊;平滑肌;收缩;镇痛;抗炎药
composite(TCD);gallbladder;smooth muscle cells;constriction;analgesia;anti-inflammatory

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作者(Author): 胡勇;李淑芳;刘迪成;
HU Yong1,LI Shufang1,LIU Dicheng2(1.Department of Pharmacology,Guiyang Medical College,Guiyang 550004,Guizhou,China;2.Department of Physiology,Guiyang Medical College,Guiyang 550004,Guizhou,China)

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DOI: 10.19367/j.cnki.1000-2707.2011.02.017

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