贵州医科大学学报

2007, (01) 31-34

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血管内皮生长因子与鼻息肉手术疗效的相关性
The Correlation between Vascular Endothelial Growth Factor and Curative Results of Nasal Polyp Operation

陈盈;田禾;陈乾美;
CHEN Ying1,TIAN He2,CHEN Qianmei2(1.Department of Otorhinolarynglogy,Guiyang First People's Hospital,Guiyang 550002,China;2.Department of Otorhinolarynglogy,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China)

摘要(Abstract):

目的:探讨血管内皮生长因子(Vascular endothelial grown factor,VEGF)在鼻息肉中的表达程度与鼻息肉手术疗效的相关性。方法:选取鼻息肉患者40例(58侧),两侧病变以病重侧计。所有病例均在鼻内窥镜下行鼻息肉摘除及窦口开放术,息肉组织常规固定并石蜡包埋后连续切片,Maxivision免疫组织化学法VEGF抗体染色。对手术疗效和VEGF染色程度进行相关性统计学分析。结果:鼻息肉中VEGF因子随着表达的增强其手术疗效越差,复发率越高。强阳性表达的复发率最高(r=0.518)。结论:鼻息肉的VEGF的表达程度可以作为预测鼻息肉患者预后指标之一。
Objective:To study the relationship between expression of vascular endothelial growth factor(VEGF) in nasal polyp cells and the curative results of nasl polyp operation. Method: Nasal polyp removing and ostium opening operations were carried out on 40 patients with nasal polyps(totally 58 sides were operated) by using nasal endoscope.The removed tissues were fixed,paraffin imbedded,and cut to sections.Maxivision immunohistochemistry staining was adopted to check the expression of VEGF.Correlation analyses were performed on the curative results and the expression of VEGF.Results: The strongly positive expression of VEGF accompanied weaker curative results and higher relapse rate,and the highest expression accompanied the highest relapse rate(r=0.518).Conclusion: The degree of VEGF expression in nasal polyp might be used as an index for the prognosis of nasal polyps after surgery.

关键词(KeyWords): 鼻息肉;鼻内镜检查;免疫组织化学;血管内皮生长因子
nasal polyps;endoscopy;immunohistochemistry;vascular endothelial growth factor

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作者(Author): 陈盈;田禾;陈乾美;
CHEN Ying1,TIAN He2,CHEN Qianmei2(1.Department of Otorhinolarynglogy,Guiyang First People's Hospital,Guiyang 550002,China;2.Department of Otorhinolarynglogy,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China)

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