刘运涌;楚兰;
LIU Yunyong,CHU lan (Department of Neurology,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China)

• 1:贵阳医学院附院神经科
• 2:贵阳医学院附院神经科 贵州贵阳550004
• 3:2006届硕士研究生
• 4:现山东省临沂市人民医院神经内科

摘要(Abstract)：

目的:探讨短暂性脑缺血发作(TIA)患者颈动脉斑块发生率、颈动脉内-中膜厚度(IMT)、颈动脉系TIA患者脑血流动力学的变化。方法:对72例TIA患者行颈部血管多谱勒超声检查,记录颈总动脉IMT、颈动脉斑块发生情况并对斑块进行分级。颈动脉系TIA患者同时行脑血流动力学的检查,按斑块分级不同记录脑血流动力学指标的变化。结果:TIA患者颈动脉斑块发生率较正常对照组升高,颈总动脉IMT较正常对照组明显增厚,斑块大小和颈总动脉IMT呈正相关。颈动脉系TIA患者脑血流动力学指标:平均血流量、动脉顺应性较对照组下降;外周阻力、临界压力较对照组升高,和斑块大小分级有关。结论:(1)TIA患者颈动脉斑块发生率高,IMT增厚明显;(2)颈动脉系TIA患者存在着脑血流动力学的改变。(3)颈动脉斑块与IMT、脑血流动力学的改变有关。
Objective: To explore the carotid plaque incidence,intima-media thickness(IMT),and cerebral hemodynamic changes in transient ischemic attack(TIA) patients,and to analyze the correlation of carotid plaque with carotid IMT,and cerebrovascular hemodynamics in TIA patients with carotid system disease.Methods: (1) Common carotid artery IMT of 72 TIA patients and 30 healthy people(as control) was checked and recorded with color duplex sonography;(2) Cerebrovascular hemodynamic indexes of patients and controls were investigated with surveying instruments;(3) The carotid artery plaques were classified into four grades according to the sizes;(4) To assess the correlation of carotid plaque with IMT cerebrovascular hemodynamic indexes in TIA patients.Results:(1) The incidence of carotid artery plaque and IMT were higher in TIA patients than in healthy people;(2) There was a positive correlation between sizes of carotid artery plaques with carotid artery IMT;(3) Among the hemodynamic indexes of patients with carotid system TIA,mean cerebral blood(Qmean),and cerebrovascular compliance(C) were lower and critical pressure(CP) and cerebrovascular resistance(R) were higher in TIA patients than in healthy people,and the changes were related with plaque sizes.Conclusions:(1) Carotid plaque is very common in patients with TIA and is positively related with IMT;(2) Hemodynamic changes occur in TIA patients with carotid system disease;(3) Carotid artery plaque relates with IMT and hemodynamic changes.

关键词(KeyWords)： 脑缺血发作,短暂性;血流动力学;内-中膜厚度;斑块
ischemic attack,transient;hemodynamics;intima-media thickness;plaque

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 刘运涌;楚兰;
LIU Yunyong,CHU lan (Department of Neurology,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China)

Email:

DOI: 10.19367/j.cnki.1000-2707.2007.05.013

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