贵州医科大学学报

2013, (02) 155-158

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CD123在组织细胞坏死性淋巴结炎中的表达及意义
Expression of CD123 and Its Significance in Histiocytic Necrocytosic Lymphadenitis

宋红杰;吴波;施晓健;崔志俊;季育娟;章如松;
SONG Hongjie1,WU Bo2,SHI Xiaojian1,CUI Zhijun1,JI Yujuan1,ZHANG Rusong2(1.Department of Pathology,People's Hospital of Haimen City,Haimen 226100,Jiangsu,China;2.Department of Pathology,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China)

摘要(Abstract):

目的:探讨CD123在组织细胞坏死性淋巴结炎(HNL)中的表达及在诊断和鉴别诊断中的价值。方法:对39例HNL患者淋巴结进行常规形态学观察和免疫组织化学标记,并以12例淋巴组织反应性增生性病变(RLH)、10例猫抓病(CSD)和12例弥漫性大B细胞淋巴瘤(DLBCL)淋巴结作为对照,比较CD123的表达。结果:CD123在组织细胞坏死性淋巴结炎中的阳性表达为89.74%,反应性淋巴组织增生性病变中为33.33%(P<0.01),猫抓病中为30%(P<0.01),弥漫性大B细胞性淋巴瘤中为16.67%(P<0.01),CD123在组织细胞坏死性淋巴结炎中表达的敏感性是89.74%,特异性是73.53%。结论:CD123在组织细胞坏死性淋巴结炎中具有较高的表达率,其敏感性和特异性较好,是诊断HNL较为理想的免疫标志物。
Objective: To investigate the expression of CD123 in histiocytic necrocytosic lymphadenitis(HNL) and its value in diagnosis and differential diagnosis of HNL.Methods: Morphological observation and Immunohistochemical staining for CD123 detection were carried out to 39 cases of HNL,while same were done to 12 cases of reactive lymphoid hyperplasia(RLH),10 cases of cat scratch disease(CSD) and 12 cases of diffuse large B-cell lymphoma(DLBCL),to collect data as control.Results: The expression rates of CD123 were 89.74% in HNL,33.3% in RLH,30% in CSD and 16.7% in DLBCL.Significant differences were observed between HNL and RLH(P<0.01),between HNL and CSD(P<0.01),and between HNL and DLBCL(P<0.01).The sensitivity and specificity of CD123 were 89.74% and 73.53% respectively.Conclusions: The expression rate of CD123 in HNL was significantly higher than those in RLH,CSD and DLBCL.CD123 has a high sensitivity and specificity and is a useful immunohisitochemical marker in the diagnosis of HNL.

关键词(KeyWords): CD123;组织细胞坏死性淋巴结炎;免疫组织化学;诊断,鉴别
CD123;histiocytic necrotizing lymphadenitis;immunohistochemistry;diagnosis,differential

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作者(Author): 宋红杰;吴波;施晓健;崔志俊;季育娟;章如松;
SONG Hongjie1,WU Bo2,SHI Xiaojian1,CUI Zhijun1,JI Yujuan1,ZHANG Rusong2(1.Department of Pathology,People's Hospital of Haimen City,Haimen 226100,Jiangsu,China;2.Department of Pathology,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China)

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