贵州医科大学学报

2020, v.45;No.239(08) 943-948

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

ET和PV患者的临床特征及血栓和出血并发症分析
Analysis of Clinical Characteristics and Complications of Thrombosis and Bleeding in Patients with ET and PV

肖捷;潘成云;李兴明;许娜;黄继贤;
XIAO Jie;PAN Chengyun;LI Xingming;XU Na;HUANG Jixian;Department of Physical Examination,the Affiliated Yuebei People's Hospital of Shantou University Medical College;Department of Hematology,the Affiliated Hospital of Guizhou Medical University;Department of Neurology,the Affiliated Yuebei People's Hospital of Shantou University Medical College;Department of Hematology,Nanfang Hospital of Southern Medical University;Department of Hematology,the Affiliated Yuebei People's Hospital of Shantou Univ

摘要(Abstract):

目的:探讨原发性血小板增多症(ET)和真性红细胞增多症(PV)患者的临床特征、血栓和出血并发症的发生规律。方法:收集合2016年世界卫生组织(WHO)诊断标准的133例ET和45例PV患者的病例资料,分析ET、PV及ET+PV患者的动静脉血栓、出血事件的发生率,检测血栓和出血事件的患者JAK2、CALR及MPL驱动基因突变情况,分析血管事件与基因突变发生率和年龄之间的相关性,分析患者驱动基因、血栓和出血事件的类型、频率及年龄分布的特点。结果:ET、PV及ET+PV患者的血栓事件发生率高于各自的出血事件发生率,ET、PV及ET+PV患者的动脉血栓事件发生率高于各自的静脉血栓事件发生率,差异均有统计学意义(P <0.01);动脉血栓事件中脑血栓事件(16.29%)最常见,有血栓事件的ET患者中,年龄和JAK2V617F基因突变率大于无事件ET患者,差异有统计学意义(P <0.05); JAK2V617F和CALR驱动基因突变双阳性的ET患者,可合并有血栓事件。结论:ET和PV患者血栓事件较出血事件更常见,其中脑血栓事件最常见;有血栓事件的ET患者的年龄更大,JAK2V617F基因突变率更高,JAK2V617F和CALR突变双阳性的ET患者可合并有血栓事件。
Objective: To investigate the clinical features,occurrence of thrombosis,and bleeding complications in patients with essential thrombocythemia( ET) and polycythemia vera( PV).Methods: Data of patients with ET and PV who met the 2016 World Health Organization( WHO)myeloproliferative neoplasms diagnostic criteria were summarized. Combined with the age,results of driver mutation detection,and head computed tomography or magnetic resonance imaging findings,the types and frequencies of driver mutations,thrombosis,bleeding events,and age distribution were analyzed. Results: Data of 133 patients with ET and 45 patients with PV were collected. The incidences of thrombotic events in patients with ET,PV,and ET + PV were significantly higher than those of bleeding events( P < 0. 01). The incidences of arterial thrombotic events in patients with ET,PV,and ET + PV were also significantly higher than those of venous thrombotic events( P < 0. 01).The most common thrombotic event was cerebral thrombosis( 16. 29%). The age and rate of JAK2 V617 F mutations in patients with ET with thrombosis were significantly higher than those in patients with ET without thrombosis( P < 0. 05). Patients with ET and concurrent JAK2 V617 F and CALR mutations may have thrombotic events. Conclusion: Thrombosis in patients with ET and PV is more prevalent than bleeding. Arterial thrombotic events are more frequent than venous thrombotic events. Cerebral thrombotic events are the most common type of arterial thrombotic events. The age and rate of JAK2 V617 F mutations in patients with ET with thrombosis are higher than those in patients with ET without thrombosis. Patients with ET and concurrent JAK2 V617 F and CALR mutations may have thrombotic events.

关键词(KeyWords): 血小板增多,自发性;红细胞增多症,真性;出血;骨髓增殖性肿瘤;血栓;基因突变
thrombocythemia,essential(ET);polycythemia vera(PV);hemorrhage;myeloproliferative neoplasms;thrombosis;gene mutation

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(81700104);; 广东省医学科研基金立项项目(A2017543);; 韶关市科技计划项目(2017cx/008,2019sn015)

作者(Author): 肖捷;潘成云;李兴明;许娜;黄继贤;
XIAO Jie;PAN Chengyun;LI Xingming;XU Na;HUANG Jixian;Department of Physical Examination,the Affiliated Yuebei People's Hospital of Shantou University Medical College;Department of Hematology,the Affiliated Hospital of Guizhou Medical University;Department of Neurology,the Affiliated Yuebei People's Hospital of Shantou University Medical College;Department of Hematology,Nanfang Hospital of Southern Medical University;Department of Hematology,the Affiliated Yuebei People's Hospital of Shantou Univ

Email:

DOI: 10.19367/j.cnki.2096-8388.2020.08.014

参考文献(References):

文章评论(Comment):

序号(No.) 时间(Time) 反馈人(User) 邮箱(Email) 标题(Title) 内容(Content)
反馈人(User) 邮箱地址(Email)
反馈标题(Title)
反馈内容(Content)
扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享