贵州医科大学学报

1993, (01) 15-19

[打印本页] [关闭]
本期目录 | 过刊浏览 | 高级检索

4-[(4-氯苯基)(5-氟-2-羟基苯基)亚甲氨基]丁酰胺的质谱研究
Study on the Mass Spectra of 4-[(4-Chlorophenyl)(5-Fluoro-2-Hydroxyphenyl) Methylene Amino] Butanamide

袁牧;钟裕国;庞其捷;李正化;
Yuan Mu, et al Department of Pharmaceutical Chemistry

摘要(Abstract):

本文对最新的γ-氨基丁酸受体激动剂,4-[(4-氯苯基)(5-氟-2-羟基苯基)亚甲氨基]丁酰胺进行了质谱研究。对其裂解规律进行了探讨。
Progabide, 4-[(4-chlorophenyl) (5-fluro-2-hydroxyphenyl) niethylene amino) butanamide, is a lipophilic compound that crosses the blood-brain barrier and possesses low toxicity. It is the first specific Y-aminobutyric acid (GABA) receptor agonist which has been undergone extensive clinical trials on epilepsy therapeutics. We have synthesized 4-[ (4-chorophenyl) (5-fluoro-2-hydroxyphenyl) methylene amino] bubanamide. The mass spectra of 4-[ (4-chlorophenyl) (5-fluoro-2-hydroxyphenyl) methylene amino) butanamide was reported and discussed. All the mass spectral fragmentations characteristics of 4-[(4-chlorophenyl) (5-fluoro-2-hydroxyphenyl) methylene amino) butanamide were assigned. It shows that the results are consistent with the chemical structure.

关键词(KeyWords): γ-氨基丁酸衍生物;普罗加比;质量光谱分析;抗惊厥药
γ-aminobutyric acid derivatives;progabide;spectrum analys(;mass;anticonvulsants

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 袁牧;钟裕国;庞其捷;李正化;
Yuan Mu, et al Department of Pharmaceutical Chemistry

Email:

文章评论(Comment):

序号(No.) 时间(Time) 反馈人(User) 邮箱(Email) 标题(Title) 内容(Content)
反馈人(User) 邮箱地址(Email)
反馈标题(Title)
反馈内容(Content)
扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享