袁牧;钟裕国;庞其捷;李正化;
Yuan Mu, et al Department of Pharmaceutical Chemistry

• 1: 贵阳医学院药物化学教研室
• 2:华西医科大学药学院
• 3:华西医科大学药学院
• 4:华西医科大学药学院

摘要(Abstract)：

本文对最新的γ-氨基丁酸受体激动剂,4-[(4-氯苯基)(5-氟-2-羟基苯基)亚甲氨基]丁酰胺进行了质谱研究。对其裂解规律进行了探讨。
Progabide, 4-[(4-chlorophenyl) (5-fluro-2-hydroxyphenyl) niethylene amino) butanamide, is a lipophilic compound that crosses the blood-brain barrier and possesses low toxicity. It is the first specific Y-aminobutyric acid (GABA) receptor agonist which has been undergone extensive clinical trials on epilepsy therapeutics. We have synthesized 4-[ (4-chorophenyl) (5-fluoro-2-hydroxyphenyl) methylene amino] bubanamide. The mass spectra of 4-[ (4-chlorophenyl) (5-fluoro-2-hydroxyphenyl) methylene amino) butanamide was reported and discussed. All the mass spectral fragmentations characteristics of 4-[(4-chlorophenyl) (5-fluoro-2-hydroxyphenyl) methylene amino) butanamide were assigned. It shows that the results are consistent with the chemical structure.

关键词(KeyWords)： γ-氨基丁酸衍生物;普罗加比;质量光谱分析;抗惊厥药
γ-aminobutyric acid derivatives;progabide;spectrum analys(;mass;anticonvulsants

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 袁牧;钟裕国;庞其捷;李正化;
Yuan Mu, et al Department of Pharmaceutical Chemistry

Email:

参考文献(References)：

• 1 Ascalone V, et al. Determination of progabide and its acid metabolite in biological fluids by high-performance liquid chromatography on silica column with ultraviolet detection. J Chromatogr. 1985, 344: 231-239
• 2 Lin-Michell E, et al. Effect of ethosurimide alone and in combi- nation with GABA receptor agonists on brain GABA concentration, anticonvulsant activity and neurotoxicity in mice, J pharmacol Exp Ther 1986, 237 (2) : 486-9
• 3 Rastogi S K, et al. Anticonvulsant profile of drugs which facilitate GABA ergic transmission on convulsions mediated by a GABA ergic mechanism. Neuropharmacology, 1986, 25 (2) : 175-185
• 4 袁牧,等.新型γ-氨基丁酸受体激动剂--Schiff碱型γ-氨基丁酰胺的合成.贵阳医学院学报,1989,14(2) :81-86

文章评论(Comment)：