贵州医科大学学报

1985, (01) 9-11

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异甲防己素抗菌抗病毒研究 二、粗制小蘖胺治疗小白鼠实验性流感的初步观察
A STUDY OF THE ANTIBACTERIAL AND ANTIVIRAL ACTIVITY OF ISOTETRANDRINE

董熙昌;刘若英;梁诗标;姚贤明;
Dong Xichang Department of Microbiology

摘要(Abstract):

<正> 我们曾用药抑空斑法复筛获得了小蘖胺等五种抗流感病毒药物。现以小白鼠为流感实验动物模型用粗制小蘖胺进行治疗,以确定其在体内的效果。材料和方法一、药物 1.粗制小蘖胺粉剂批号7802粗制小蘖胺粉剂系以三颗针提取黄连硷后的废液中粗提制得,批号7811样品系由十大功劳提取黄连硷后的废液中粗提制得,二者均由贵阳制药厂供给。 2.粗制小蘖胺药液取粗制小蘖胺1克,加蒸馏水100毫升,用NHCI调pH至3左右,加热溶解、
2. A Preliminary Survey of the Therapeutic effect of Crude Barbamine on Influenza of Experimental Mice On the basis that the extracts of five kinds of Chinese herbs tested are effec- tive in inhibiting the plaque fomation of influenza virus, strain FMI, We have tested one of them, a crudely prepared barbamine, it's antiviral activity against infection of influenza virus in mice. It was noticed that the drug is rather effective give in the theraputic doses, but the laboratory testing method in Institute of Materia Mediea of CAMS we have followed needs to be improved Furthermore the Crude barbamine has been Purified into an effective, white pow-dered fraction as isotetrandrine by Guiyang Pharmaceutical Factory.

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作者(Author): 董熙昌;刘若英;梁诗标;姚贤明;
Dong Xichang Department of Microbiology

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DOI: 10.19367/j.cnki.1000-2707.1985.01.002

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