贵州医科大学学报

1999, (03) 241-242

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紫珠止血作用的实验研究
Experimental Study of Callicarpa Pedunculata R.Br.on Stanching Effect

素琳,钟恒亮,夏曙华,王荔平
Lu Sulin, et al Department of Pharmacology,Guiyang Medical College

摘要(Abstract):

用紫珠 5,10 ,2 0 g生药·kg- 1体重给小鼠连续灌胃 1周 ,分别测定小鼠的凝血时间和出血时间 ,并进行血小板计数。结果紫珠各剂量组和对照组比较 ,凝血时间和出血时间明显缩短 (P <0 0 5,P <0 0 1,P <0 0 0 1) ,血小板计数明显增高 (P <0 0 5,P <0 0 1)。结果表明 :紫珠有明显的止血作用和升高血小板作用 ,提示紫珠升高血小板作用是其止血机理之一 ,也是其治疗血小板减少性出血的药理基础。
To observe the stanching effect of callicarpa pedunculate R.BR.(CP) on mice.The mice were given orally with CP 5g/kg(low dose group),10g/kg(moderate dose group)and 20g/kg(high dose group)per day,for 7 days.The coagulation time was measured using the capillary method and the bleeding time was measured using Tian Dao improved method. Platelets were count in the mice.As a result,the coagulation time and bleeding time in the CP three groups are significantly shorter than those in the normal saline group (P<0 05,P<0 01,P<0 001).CP could increase platelets of mice (P<0 05,P<0 01).The experimental results indicated that CP had stanching effect and the effect of raising platelets.

关键词(KeyWords): 血小板;出血时间;凝血时间;紫珠
blood platelets;bleeding time;coagulation time;callicarpa pedunculata R Br

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作者(Author): 素琳,钟恒亮,夏曙华,王荔平
Lu Sulin, et al Department of Pharmacology,Guiyang Medical College

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