贵州医科大学学报

2018, v.43;No.208(01) 41-45

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OBFC1基因多态性与脑胶质瘤患病风险的相关性
Correlation of Genetic Polymorphism in OBFC1 with Risk of Glioma

李国林;李超;李峰;
LI Guolin;LI Chao;LI Feng;Central Hospital of the Mining Bureau in Tongchuan;

摘要(Abstract):

目的:研究OBFC1基因多态性与脑胶质瘤患病风险的相关性。方法:选择脑胶质瘤患者200例和健康对照人群200例,分别采集血样,采用Mass ARRAY方法对OBFC1基因的rs9325507、rs3814220、rs12765878、和rs11191865位点的基因型进行测定,采用χ2检验比较两组被检者四个位点等位基因频率差异,统计基因多态性与脑胶质瘤患病风险的相关性。结果:OBFC1基因rs9325507位点的等位基因"T",rs3814220位点的等位基因"G",rs12765878位点的等位基因"C"和rs11191865位点的等位基因"A"均显著降低脑胶质瘤的患病风险(P<0.05);引入遗传模型后,在最佳模型-显性模型下rs9325507位点携带T/C和T/T基因型个体的脑胶质瘤患病风险显著降低,是携带C/C基因型的0.62倍;rs3814220位点携带G/A和G/G基因型个体的脑胶质瘤患病风险显著降低,是携带A/A基因型的0.62倍;rs12765878位点携带C/T和C/C基因型个体的脑胶质瘤患病风险显著降低,是携带T/T基因型的0.62倍;rs11191865位点携带A/G和A/A基因型个体的脑胶质瘤患病风险显著降低,是携带G/G基因型的0.65倍;单体型分析结果显示TGCA单体型会显著降低脑胶质瘤的患病风险。结论:OBFC1基因上rs9325507、rs3814220、rs12765878、和rs11191865位点与降低脑胶质瘤的患病风险可能具有相关性。
Objective: To investigate the association between single nucleotide polymorphisms( SNPs) in OBFC1 and risk of glioma. Methods: A total of 200 patients with glioma and 200 healthy controls were enrolled in Kuangwu Hospital of Tongchuan from January 2012 to December 2016. Blood samples were collected. The genotypes of rs9325507,rs3814220,rs12765878,and rs1119186 were genotyped by Mass ARRAY method,and the association between SNPs and risk of glioma was evaluated by χ2 test of SPSS 19. 0. Results: The allele frequencies of SNPs between cases and controls were compared by using χ2 test. The allele " T" of rs9325507,the allele " G" of rs3814220,the allele " C" of rs12765878 and the allele " A" of rs11191865 were significantly associated with decreased risk of glioma( P < 0. 05). In the genetic model analysis,under the best model-dominant model,carrying T/C and T/T genotypes of rs9325507 showed decreased risk of glioma,as compared with carrying C/C genotype( OR = 0. 62,95% CI: 0. 43 ~ 0. 90,P = 0. 012); carrying G/A and G/G genotypes of rs3814220 showed decreased risk of glioma,compared with carrying A/A genotype( OR = 0. 62,95%CI: 0. 43 ~ 0. 91,P = 0. 014); carrying C/T and C/C genotypes of rs12765878 showed decreased risk of glioma,compared with carrying T/T genotype( OR = 0. 62,95% CI: 0. 43 ~ 0. 90,P = 0. 012); carrying A/G and A/A genotypes of rs11191865 showed decreased risk of glioma,compared with carrying G/G genotype( OR = 0. 65,95% CI: 0. 45 ~ 0. 94,P = 0. 023). Finally,the haplotype analysis results showed that the haplotype " TGCA " constructed by rs9325507, rs3814220, rs12765878, and rs1119186 were significantly associated with decreased risk of glioma( OR = 0. 76,95% CI: 0. 58 ~ 0.99,P = 0. 044). Conclusion: The rs9325507,rs3814220,rs12765878,and rs1119186 in OBFC1 may be associated with decreased risk of glioma.

关键词(KeyWords): 脑肿瘤;基因型;OBFC1;单核苷酸多态性;关联分析
brain tumor;gentype;OBFC1;single nucleotide polymorphisms;correlation analysis

Abstract:

Keywords:

基金项目(Foundation): 陕西省科技攻关基金资助项目(2016SF-110)

作者(Author): 李国林;李超;李峰;
LI Guolin;LI Chao;LI Feng;Central Hospital of the Mining Bureau in Tongchuan;

Email:

DOI: 10.19367/j.cnki.1000-2707.2018.01.009

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