贵州医科大学学报

2016, v.41;No.192(09) 1108-1110+1114

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乌司他丁对食管癌术后炎症的治疗效果
Clinical Efficacy of Ulinastatin on Inflammatory after Resection of Esophageal Cancer

廖泽飞;林勇龙;马良赟;
LIAO Zefei;LIN Yonglong;MA Liangyun;Department of Thoracic Surgery,Quanzhou 180th Hospital of PLA;

摘要(Abstract):

目的:评价乌司他丁(UTI)对食管癌术后炎症的影响。方法:100例食管癌手术患者均分为治疗组和对照组,治疗组在手术前30 min给予UTI 100 000单位静脉滴注,并于术后当天~第3天,再次给予持续静脉泵入UTI,对照组于同时点给予等量生理盐水;所有患者于术前、术后第1天及术后第7天检测血清中性粒细胞弹性蛋白酶活性(NE)、白细胞介素-6(IL-6)及IL-8的浓度,于术后第1天、第3天检测气管肺泡灌洗液(BALF)中的NE浓度。结果:两组患者术前血清IL-6、IL-8及NE比较,差异无统计学意义(P>0.05);与术前比较,治疗后两组患者血清NE浓度升高,第1天高于第7天(P<0.01);治疗后,治疗组同时点血清IL-6、IL-8水平升高的幅度小于对照组(P<0.05);治疗后,BALF中的NE浓度第1天高于第3天,且治疗组低于对照组(P<0.05)。结论:UTI可降低食管癌患者手术后血清和BALF中炎症因子水平、抑制过度炎性创伤反应。
Objective: To evaluate the effect of ulinastatin on inflammatory reaction after resection of esophageal carcinoma. Methods: 100 esophageal carcinoma patients were randomly divided into two groups. In the treatment group,ulinastatin 100 000 Unit was intravenously infused 30 min before operation,and 200 000 U / d. continuous infusion after operation for 3 days. In the control group,normal saline followed the same protocols. Serum neutrophil elastase( NE),interlukin( IL)-6,IL-8 and neutrophil elastase of bronchoalveolar lavage fluid were respectively compared before,1 d and 7 d after treatment; NE concentration level was detected 1 d and 3 d after operation. Results: Comparing NE with serum IL-6 and IL-8 before operation in both groups was not statistically significant( P > 0. 05).Comparing with before operation,NE concentration level increased in both groups,1stday was higher than 7thday( P < 0. 01); after treatment,increase level of serum IL-8 and IL-6 in treatment group at same time point was lower than control group( P < 0. 05); NE of bronchoalveolar lavage fluid in treatment group,1stday was higher than 3rdday,was significantly smaller than in control group( P <0. 05). Conclusion: The use of ulinastatin can reduce the inflammatory factors,inhibit inflammatory response.

关键词(KeyWords): 食管肿瘤;乌司他丁;炎症;急性肺损伤;手术后并发症
esophageal neoplasms;ulinastatin;inflammation;acute lung injury;postoperative complications

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基金项目(Foundation): 泉州市科技计划项目(2012z66)

作者(Author): 廖泽飞;林勇龙;马良赟;
LIAO Zefei;LIN Yonglong;MA Liangyun;Department of Thoracic Surgery,Quanzhou 180th Hospital of PLA;

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