信号转导与转录激活因子3在肿瘤发生发展中的研究进展
张启芳;
摘要(Abstract):
<正>信号转导与转录激活因子3(signal transducer and activator of transcription 3,STAT3)最早在白介素-6(interleukin-6,IL-6)诱导的肝细胞急性时相反应(acute phase response)中被发现[1-2],随后发现STAT3被干扰素调节发挥效应[3]。STAT3蛋白在许多小鼠和人肿瘤细胞呈持续性激活状态(被
关键词(KeyWords):
信号转导与转录激活因子3;肿瘤;免疫抑制;肿瘤微环境
基金项目(Foundation): 国家自然科学基金项目(No.81560482);; 贵州省“2011协同创新中心”支助项目[黔教合协同创新中心(2014)06];; 贵州省科技厅重大专项[黔科合计Z字(2012)4010];; 贵州省科技厅计划项目[黔科合LG字(2012)009]
作者(Author):
张启芳;
Email:
DOI: 10.19367/j.cnki.1000-2707.2015.11.002
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