贵州医科大学学报

2003, (04) 292-295

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卡维地洛对心衰大鼠心肌细胞凋亡和凋亡相关基因表达的影响
Effects of Carvedilol on Cardiac Myocyte Apoptosis and the Expression of Apoptosis - associated Gene during Heart Failure in Rats

吴强,李隆贵,蔡运昌,杨天和,王晓峰,耿召华
WU Qiang, LI Long-gui, CAI Yun-chang, YANG Tian-he, WANG Xiao-feng, GENG Zhao-hua (1. Department of Cardiology, Guizhou Provincial People' s Hospital, Guiyang 550002 , China; 2. Department of Cardiology, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China)

摘要(Abstract):

目的:探讨卡维地洛(CAR)对心肌梗塞(MI)后充血性心力衰竭(CHF)大鼠心肌细胞凋亡的影响及其作用机制。方法:将雄性Waistar大鼠前降支结扎,于术后1周开始予CAR和美托洛尔(MET)干预7周,观察CAR和MET对大鼠心肌细胞凋亡、Fas、FasL和Bcl-2的mRNA和蛋白表达的影响。结果:CAR和MET都可不同程度地降低心肌细胞凋亡指数,但CAR降低心肌细胞凋亡指数、Fas及FasL的mRNA水平、上调Bcl-2表达效果优于MET。结论:CAR可有效地减少MI后心肌细胞凋亡、防治CHF,这与其抑制Fas和FasL表达、促进Bcl-2表达有关。
Objective: To study the effects of carvedilol (CAR) on cardiac myocyte apoptosis during congestive heart failure (CHF) subsequent to myocardial infarction (MI) in rats, and its mechanisms. Methods: Animal models of MI were established by ligating the left coronary artery of male waistar rats. Those animal models were randomly divided into control group (MI) that did not receive any treatment for MI, and experimental groups which received carvedilol (CAR) , and metoprolol (MET) , respectively for 7 weeks since 1 week after the operation. Cardiac myocyte apoptosis was observed, and the mRNA of proteins of Fas, FasL and Bcl-2 were investigated at the 8th week after operation. Results: The apoptosis index of rats in Both CAR and MET groups decreased. The number of myocytes apoptosis and the levels of mRNA of Fas, FasL were significantly lower and that of Bcl-2 was markedly higher in CAR group than those in MET group. Conclusion: CAR could effectively decrease myocard-iocyte apoptosis, prevent and treat CHF which might relate to the reduction of the expression of Fas and FasL, and the increase of Bcl-2 expression.

关键词(KeyWords): 心肌;心力衰竭;充血性;细胞调亡;基因表达;心肌梗塞;肾上腺素能β拮抗剂;肾上腺素能α拮抗剂;大鼠
myocardium; heart failure, congestive; apoptosis; gene expression; adrenergic beta-antagonists; adrenergic alpha-antagonists; rats

Abstract:

Keywords:

基金项目(Foundation): 贵州省科学技术基金资助项目 (No.3044)

作者(Author): 吴强,李隆贵,蔡运昌,杨天和,王晓峰,耿召华
WU Qiang, LI Long-gui, CAI Yun-chang, YANG Tian-he, WANG Xiao-feng, GENG Zhao-hua (1. Department of Cardiology, Guizhou Provincial People' s Hospital, Guiyang 550002 , China; 2. Department of Cardiology, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China)

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DOI: 10.19367/j.cnki.1000-2707.2003.04.004

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