贵州医科大学学报

2004, (04) 308-309+312

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Fas在胆脂瘤型中耳乳突炎中的表达及意义
The Expression of Fas in Middle Ear Cholesteatoma Epithelium and Its Significance

叶惠平,陈乾美,蒋科慧,范陆,林尚泽
YE Hui ping 1, CHEN Qian mei 1, JIANG Ke hui 2, FAN Lu 1, LIN Shang ze 1 (1. Department of Otolaryngology, The Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China; 2.Department of Otolaryngology of Zunyi Hospital, Zunyi 563001, China)

摘要(Abstract):

目的 :探讨Fas在中耳继发胆脂瘤上皮中的表达及其在胆脂瘤型中耳乳突炎发病中的作用。方法 :利用免疫组化的方法 ,检查 32例胆脂瘤上皮和 1 1例正常外耳道皮肤中的Fas蛋白的表达情况。结果 :Fas阳性细胞主要在 2 9例胆脂瘤上皮的颗粒层和角质层中 ,阳性细胞率为 (2 1 0± 1 3 8) % ,在 3例胆脂瘤上皮和 1 1例外耳道皮肤中为阴性 ,差异具有显著性 (P <0 0 5 )。结论 :Fas在胆脂瘤上皮表达增高 ,与胆脂瘤中角化物的堆积有关。
Objective: To investigate the role of Fas in the etiology of middle ear cholesteatoma. Methods: The expression of Fas in the cholesteatoma epithelium (n=32) and in the skin of the external ear canal (n=11) were observed with immunohistochemical technique. Results: Fas protein expressed in 29 samples of cholesteatoma epithelia (29/32), whereas the other 3 samples of cholesteatoma epithelia and samples of external ear canal skin showed negative reaction. There was significant difference of Fas expression between the two groups (P<0.05) . Conclusion: The accumulation of keratin debris is due to increased karatotic substances related to Fas protein.

关键词(KeyWords): 胆脂瘤,中耳;Fas;角化物
cholesteatoma,middle ear; Fas; apoptosis

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作者(Author): 叶惠平,陈乾美,蒋科慧,范陆,林尚泽
YE Hui ping 1, CHEN Qian mei 1, JIANG Ke hui 2, FAN Lu 1, LIN Shang ze 1 (1. Department of Otolaryngology, The Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China; 2.Department of Otolaryngology of Zunyi Hospital, Zunyi 563001, China)

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