贵州医科大学学报

2018, v.43;No.214(07) 860-863

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唑来膦酸治疗绝经后骨质疏松症的疗效
Clinical Efficacy of Zoledronic Acid in the Treatment of Postmenopausal Women with Osteoporosis

单宇;张晓剑;朱立帆;
SHAN Yu;ZHANG Xiaojian;ZHU Lifan;Department of Orthopedics,the First People's Hospital of Wujiang & Affiliated Wujiang Hospital to Nantong University;

摘要(Abstract):

目的:观察唑来膦酸治疗绝经后骨质疏松症妇女的疗效。方法:选择70例绝经后骨质疏松症患者,根据年龄分为51~60岁组(15例)、61~70岁组(35例)和71~83岁组(20例),采用唑来膦酸静脉滴注治疗,1次/年;采用双能X线仪测定治疗前及治疗后1年患者的腰椎(L2~L4)和股骨颈骨密度(BMD)值,并进行骨痛VAS评分和生活质量ECOS-16评分,观察患者治疗后的不良反应。结果:与治疗前比较,治疗1年后3个年龄组骨质疏松症患者的腰椎(L2~L4)和股骨颈BMD增加,疼痛、身体机能、对疾病的恐惧及心理机能方面的ECOS-16评分均下降,差异有统计学意义(P<0.05);治疗后VAS评分显示,显效29例,有效32例,疼痛缓解总有效率为87.1%;发热为最常见的不良反应。结论:唑来膦酸治疗绝经后骨质疏松症能显著改善患者骨量、减轻患者的疼痛、改善患者生活质量,安全性较好。
Objective: To observe the efficacy of zoledronic acid in the treatment of postmenopausal women with osteoporosis. Methods: 70 patients with postmenopausal osteoporosis were divided into 51~ 60 years old group( 15 cases),61 ~ 70 years old group( 35 cases) and 71-83 year old group( 20 cases),using zoledronic acid intravenous drip treatment,1 time per year. The lumbar( L2 ~ L4) and femoral neck bone mineral density( BMD) was measured by dual energy X ray before and 1 year after treatment. The bone pain VAS score and quality of life ECOS-16 score were used to observe the adverse reactions after treatment. Results: Compared with before treatment,the lumbar( L2 ~ L4) and femoral neck BMD increased in 3 age groups after 1 year treatment. The ECOS-16 scores of pain,body function,fear of disease and psychological function were all decreased,and the differences were statistically significant( P < 0. 05). After treatment,the VAS score showed that 29 cases showed significant effect and 32 cases showed effective,the total effective rate of pain relief was 87. 1%. Fever was the most common adverse reaction. Conclusion: Zoledronic acid can significantly improve bone mass,relieve pain and improve the quality of life of patients with postmenopausal osteoporosis.

关键词(KeyWords): 唑来膦酸;绝经期;骨密度;骨质疏松症;疗效
zoledronic acid;menopause;bone density;osteoporosis;efficacy analysis

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作者(Author): 单宇;张晓剑;朱立帆;
SHAN Yu;ZHANG Xiaojian;ZHU Lifan;Department of Orthopedics,the First People's Hospital of Wujiang & Affiliated Wujiang Hospital to Nantong University;

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DOI: 10.19367/j.cnki.1000-2707.2018.07.026

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