氟铝联合作用时氟与不同种类铝化合物在代谢中相互作用的差异The Difference of Combined Effects on Metabolism between the Fluoride and Different Aluminum Compounds
徐恩良;魏赞道;周琳业;张华;王绍鑫;吴发义;方士杰;程学方;赵方贵;
Xu Enliang, et al Department of Preventive Medicine
摘要(Abstract)：
59只兔随机分为对照、氟组、低铝氟组和高铝氟组。经14周亚慢性毒性实验,发现氟和铝在吸收、蓄积及排泄中均产生相互作用,并对Fe、Ca、P等元素产生影响。对照组骨灰铝为43.11ppm,氟组为83.13ppm,低铝氟组为52.45ppm,高铝氟组为32.33ppm。表明氟能促进饲料中本底铝在骨中蓄积,硫酸铝能拮抗这种作用。作者认为铝在氟中毒骨骼病变中有重要作用。
Fifty-nine rabbits were divided into 4 groups: control (C) , fluoride (F) lower aluminum-fluoride (L) and higher aluminum-fluoride (H) group, and were subjected to subchronic toxicity experiment for 14 weeks. We found that fluoride and aluminum affected each other on their absorption, accmulation and excretion. They aiso affected the metabolisms of Fe, Ca and P. The content of aluminum in the bone was 43.11ppm in the C group, 83.13ppm, F group, 52.45ppm, L group and 32.33ppm, H group.The results showed that fluoride promoted the deposition of natural aluminum compounds of food in the bone, while aluminum sulfate antagonised this effect. We considered that aluminum might play an important role in the pathogenesis of skeletal fluorosis.
关键词(KeyWords)：
氟化物中毒;铝;兔
fluoride poisoning; aluminum; rabbit
基金项目(Foundation):
作者(Author):
徐恩良;魏赞道;周琳业;张华;王绍鑫;吴发义;方士杰;程学方;赵方贵;
Xu Enliang, et al Department of Preventive Medicine
Email:
DOI: 10.19367/j.cnki.1000-2707.1991.03.008
参考文献(References)：
- 1． 戴国友,等.氟铝联合作用实验研究.贵阳医学院学报 1990;15(2) :81-88．
- 2． 蔡宏道,主编.中国医学百科全书环境卫生学.上海:上海科学技术出版社,1987:13,61。
- 3． Spencer H, et al. Effect of aluminum hydroxide on fluoride metabolism. Clin Pharmacol Ther 1980; 78 (4) : 529．
- 4． 李国林,等。药物缓解山羊氟中毒的试验.全国畜间氟防学术讨论会论文集 包头:中国兽医学会编 1987。
- 5． 李祚煌,等.工业氟污染区山羊慢性氟中毒综合防治试验.出处同上。
- 6． 曾桐,等.山羊慢性氟中毒人工复制病例的药物防治研究.出处同上.
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