贵州医科大学学报

2013, (01) 27-30+34

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阿托伐他汀对急性冠状动脉综合征患者血红素氧合酶和Th细胞的影响
Eftect of Atorvastatin on Heme Oxygenase-1,and T Helper Cells of Patients with Acute Coronary Syndrome

刘大男;吴立荣;方颖;刘兴德;李屏;
LIU Danan,WU Lirong,FANG Ying,LIU Xingde,LI Ping(Department of Cardiology,the Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

摘要(Abstract):

目的:探讨阿托伐他汀对急性冠脉综合征(ACS)患者血红素氧合酶-一氧化碳(HO-1/CO)系统、1型-2型辅助性T细胞(Thl/Th2)及其细胞因子(IFN-γ、IL-2、IL-4、IL-10)的影响。方法:207例ACS患者随机分为阿托伐他汀治疗组(104例)和对照组(103例),检测治疗前后外周血Thl/Th2频率及其相关细胞因子、HO-1、CO浓度及血脂等指标。结果:(1)两组治疗前后血脂水平变化均无显著性(P>0.05);(2)与治疗前及对照组比较,阿托伐他汀组Thl频率、IFN-γ、IL-2水平显著下降,而HO-1、CO和IL-10水平均显著升高(P<0.01),Th2(IL-4)频率差异无统计学意义(P>0.05)。结论:阿托伐他汀既能调节ACS患者Thl/Th2分化失衡,又能促进HO-1/CO系统表达,从而发挥免疫调节、抑制炎症反应、改善内皮功能等心血管保护作用。
Objective: To investigate the influence of atorvastatin on heme oxygenase-1/carbon monoxide(HO-1/CO) system and T helper cells(Th) and their cell factors of patients with acute coronary syndrome(ACS).Methods: Two hundred and seven patients with ACS were randomly divided into atorvastatin group and control group.Thl/Th2 cell frequencies,related cytokine concentrations in peripheral blood,and levels of HO-1,CO and lipid were detected before and after treatment of atorvastatin.Results: Lipid levels did not change significantly in the two groups(P>0.05).Levels of HO-1,CO and IL-10 increased significantly,while Levels of IFN-γ and IL-2,and Thl cell frequency decreased significantly in atorvaststin group than these in the control group(P<0.01).There was not statistically significant difference of Th2 cell frequency between the two groups(P>0.05).Conclusions: Atorvastatin could modulate imbalance of Thl/Th2,and promote expressions of HO-1and CO as well,which can educe protective function to heart and blood vessels including immuno-modulating reaction,inflammation inhibit,and endothelial function improvement.

关键词(KeyWords): 急性冠状动脉综合征;血红素氧合酶;一氧化氮;T淋巴细胞;阿托伐他汀
acute coronary syndrome;heme oxygenase;nitric oxide;T-1ymphocytes;atorvastatin

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基金项目(Foundation): 贵州省科技教育人才省长资金项目[黔科专合字(2007)72号];; 贵州省科学基金资助项目[黔科合字(2006)2074号]

作者(Author): 刘大男;吴立荣;方颖;刘兴德;李屏;
LIU Danan,WU Lirong,FANG Ying,LIU Xingde,LI Ping(Department of Cardiology,the Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

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