贵州医科大学学报

2016, v.41;No.188(05) 603-605+614

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血清白细胞介素17与儿童哮喘严重程度的相关性
The Relationship Between Serum IL-17 levels and Childhood Asthma Severity

骆莺;张淑平;石洁;段志倩;郑建勇;
LUO Ying;ZHANG Shuping;SHI Jie;DUAN Zhiqian;ZHENG Jianyong;Department of Quality Control,Nanjing Red Cross Blood Center;Department of Laboratory Medicine,Nanjing Children's Hospital;

摘要(Abstract):

目的:观察不同程度哮喘患儿血清白细胞介素17(IL-17)水平,探讨其与儿童哮喘严重程度的相关性。方法:选择176例哮喘患儿,根据支气管哮喘全球防治但是创议(GINA)指南将其分为轻度间歇性哮喘组(n=63)、轻度持续性哮喘组(n=61)和中度-重度持续性哮喘组(n=52),同时招募32例健康体检儿童作为健康对照组,检测所有儿童血清IL-17水平及外周血单个核细胞中CD4~+IL-17A~+T细胞的数量。结果:持续性哮喘组患儿血清IL-17水平和外周血单个核细胞中CD4~+IL-17A~+T细胞数量均明显高于间歇性哮喘组患儿和健康对照组儿童,差异有统计学意义(P<0.05),且随着哮喘症状的加剧,患儿血清IL-17水平和CD4~+IL-17A~+T细胞数量逐渐升高。结论:血清IL-17水平与CD4~+IL-17A~+T细胞数量可作为儿童哮喘的联合指标,对提示儿童持续性哮喘具有潜在的应用价值。
Objective: To observe serum IL-17 levels of children with different severity of asthma and explore the relationship between serum IL-17 levels and the severity of asthma. Methods: 176 cases of asthmatic children were selected and divided into the mild intermittent group( n = 63),mild persistent group( n = 61),and moderate to severe persistent group( n = 52) according to the guideline of GINA.Meanwhile,32 healthy children were recruited as controls for the study. The serum IL-17 levels and the number of CD4~+IL-17A~+T cells in PBMCs were detected for children with asthma and healthy children. Results: The serum IL-17 levels and the number of CD4~+IL-17A~+T cells in PBMCs were significantly higher in persistent asthmatic patients than their counterparts in intermittent asthmatics and healthy controls( P < 0. 05). And with intensification of asthma symptoms,the serum IL-17 levels and the number of CD4~+IL-17A~+T cells in PBMCs were increased. Conclusions: Serum IL-17 levels and the number of CD4~+IL-17A~+T cells can be used as combined markers of children asthma,which has potential application value in predicting persistent asthmatics of children.

关键词(KeyWords): 白细胞介素17;儿童;哮喘;CD4+IL-17A+T细胞;血清
interleukin-17;child;asthma;CD4+IL-17A+T cells;serum

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作者(Author): 骆莺;张淑平;石洁;段志倩;郑建勇;
LUO Ying;ZHANG Shuping;SHI Jie;DUAN Zhiqian;ZHENG Jianyong;Department of Quality Control,Nanjing Red Cross Blood Center;Department of Laboratory Medicine,Nanjing Children's Hospital;

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DOI: 10.19367/j.cnki.1000-2707.2016.05.029

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