贵州医科大学学报

2009, (03) 297-299

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贵州省汉族人群载脂蛋白M启动子T-778C基因多态性与冠心病的相关性研究
A Study on the Associativity of Apolipoprotein M gene pormoter T-778C Polymorphism with Coronary Heart Disease among Han People of Guizhou

黄健;张姝;黄韻祝;韩昉;郑莹莹;江杰;
HUANG Jian,ZHANG Shu,HUANG Yunzhu,HAN Fang,ZHENG Yingying,JIANG Jie (Department of Clinic Biochemistry,Guiyang,Medical College,Guiyang 550004,Guizhou,China)

摘要(Abstract):

目的:探讨贵州省汉族人群载脂蛋白M(apoM)基因启动子区域-778位点T→C置换与冠心病的关系。方法:用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)对220例冠心病患者和195例健康对照者的apoM启动子-778位点进行基因筛查。结果:冠心病病例组中apoM启动子基因-778位点C等位基因的频率显著高于健康对照组(19.1%和12.6%,P=0.011)。结论:apoM启动子基因-778位点携带C等位基因可能是冠心病的一个危险的遗传易感因子。
Objective: To investigate the relationship between apolipoprotein M(apoM) gene promoter T-778C polymorhpism and coronary heart disease(CHD) in Han people of Guizhou.Methods: PCR-RFLP was adopted to analyze apoM gene pormoter T-778C polymorphism in 220 CHD patients(CHD group) and 196 healthy people(control group).Results: C allele frequency of apoM T-778 was higher in CHD group(19.1%)than that in control group(12.6%)(P=0.011).Conclusions: C allele at nucleotide-778 of apoM promoter might be a risk factor for genetic susceptibility to CHD.

关键词(KeyWords): 载脂蛋白类;转录启动子;冠状动脉疾病;心脏病
apolipoproteins;transcription initiation site;coronary disease;heart disease

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基金项目(Foundation): 贵州省卫生厅优秀医学青年科技人才专项科研基金(G2008-12);; 大学生创业基金(T2008-15-24)。

作者(Author): 黄健;张姝;黄韻祝;韩昉;郑莹莹;江杰;
HUANG Jian,ZHANG Shu,HUANG Yunzhu,HAN Fang,ZHENG Yingying,JIANG Jie (Department of Clinic Biochemistry,Guiyang,Medical College,Guiyang 550004,Guizhou,China)

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