贵州省汉族人群载脂蛋白M启动子T-778C基因多态性与冠心病的相关性研究A Study on the Associativity of Apolipoprotein M gene pormoter T-778C Polymorphism with Coronary Heart Disease among Han People of Guizhou
黄健;张姝;黄韻祝;韩昉;郑莹莹;江杰;
HUANG Jian,ZHANG Shu,HUANG Yunzhu,HAN Fang,ZHENG Yingying,JIANG Jie (Department of Clinic Biochemistry,Guiyang,Medical College,Guiyang 550004,Guizhou,China)
摘要(Abstract):
目的:探讨贵州省汉族人群载脂蛋白M(apoM)基因启动子区域-778位点T→C置换与冠心病的关系。方法:用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)对220例冠心病患者和195例健康对照者的apoM启动子-778位点进行基因筛查。结果:冠心病病例组中apoM启动子基因-778位点C等位基因的频率显著高于健康对照组(19.1%和12.6%,P=0.011)。结论:apoM启动子基因-778位点携带C等位基因可能是冠心病的一个危险的遗传易感因子。
Objective: To investigate the relationship between apolipoprotein M(apoM) gene promoter T-778C polymorhpism and coronary heart disease(CHD) in Han people of Guizhou.Methods: PCR-RFLP was adopted to analyze apoM gene pormoter T-778C polymorphism in 220 CHD patients(CHD group) and 196 healthy people(control group).Results: C allele frequency of apoM T-778 was higher in CHD group(19.1%)than that in control group(12.6%)(P=0.011).Conclusions: C allele at nucleotide-778 of apoM promoter might be a risk factor for genetic susceptibility to CHD.
关键词(KeyWords):
载脂蛋白类;转录启动子;冠状动脉疾病;心脏病
apolipoproteins;transcription initiation site;coronary disease;heart disease
基金项目(Foundation): 贵州省卫生厅优秀医学青年科技人才专项科研基金(G2008-12);; 大学生创业基金(T2008-15-24)。
作者(Author):
黄健;张姝;黄韻祝;韩昉;郑莹莹;江杰;
HUANG Jian,ZHANG Shu,HUANG Yunzhu,HAN Fang,ZHENG Yingying,JIANG Jie (Department of Clinic Biochemistry,Guiyang,Medical College,Guiyang 550004,Guizhou,China)
Email:
DOI: 10.19367/j.cnki.1000-2707.2009.03.017
参考文献(References):
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- 黄健
- 张姝
- 黄韻祝
- 韩昉
- 郑莹莹
- 江杰
HUANG Jian- ZHANG Shu
- HUANG Yunzhu
- HAN Fang
- ZHENG Yingying
- JIANG Jie (Department of Clinic Biochemistry
- Guiyang
- Medical College
- Guiyang 550004
- Guizhou
- China)
- 黄健
- 张姝
- 黄韻祝
- 韩昉
- 郑莹莹
- 江杰
HUANG Jian- ZHANG Shu
- HUANG Yunzhu
- HAN Fang
- ZHENG Yingying
- JIANG Jie (Department of Clinic Biochemistry
- Guiyang
- Medical College
- Guiyang 550004
- Guizhou
- China)