贵州医科大学学报

1993, (01) 31-34

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千金藤素在大鼠体内的代谢动力学研究
Pharmacokinetic Studies of Cepha anthine in Rats

罗俊;夏炳南;
Luo Jun,Xia Bingnan Department of Pharmacology

摘要(Abstract):

大鼠实验表明:静注千金藤素,血药浓度-时间曲线符合开放式二室模型。T1/2α为0.88min,T1/2β为226.87min,Cl为0.0133L/min,Vd为4.34L。12h胆汁、48h尿、粪的原形药物累积排出量分別为给药量的0.46、1.9及1.78%。
The pharmacokinetic study of eepharanthine was carried out by means of acidic dye colorimetry of alkaloids.After intravenous injection of the cepharanthine in rats, the data of blood drug concentration versus time were treated with a computer and were fitted to two-compartment open model according to computer's analysis.The pharmacokinetic parameters were T1/2 α, 0.88min; T1/2β,226.875min;Cl,0.0133L/min; α,0.587min~(-1);β, 0.00306mm~(-1);Vc,0.1883 L;V (d)ss, 3.842L. After gastrogavage of cepharanthine, the peak lever of the drug occurred within 48h in the following tissues in concentration of ascending order:testis, blood, brain, heart, kidney, spleen, liver and lung. The drug can distribute rapidly and extensively to tissues, even passing through the blood-braiu barrier. After gastrogavage of cepharanthine, the cumulative quantity of excretion of the unchanged drug was 1.9% and 1. 7 % of the total dose in urine and feces in 48h, and 0.46% in bile in 12h.

关键词(KeyWords): 千金藤素;药代动力学;大鼠
cepharanthine;pharmacokinetics;rats

Abstract:

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作者(Author): 罗俊;夏炳南;
Luo Jun,Xia Bingnan Department of Pharmacology

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DOI: 10.19367/j.cnki.1000-2707.1993.01.006

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