贵州医科大学学报

2007, No.128(05) 478-479+483

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葛根素联合脑复康治疗血管性认知功能障碍的疗效
An Observation of Therapeutic Effects of Puerarin and Piracetam on Vascular Cognitive Impairment

胡少瑾;李素芳;
HU Shaojin1,LI Sufang2(1.Department of Internal Medicine,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China;2.Department of Neurology,The Third Affiliated Hospital of Xinxiang Medical College,Xinxiang 453003,China)

摘要(Abstract):

目的:了解葛根素对血管性认知功能障碍(VCI)血流动力学的影响。方法:120例血管性认知功能障碍患者随机分为2组,对照组用脑复康治疗,实验组加用葛根素治疗,药物用量为0.5 g加入250 ml液体中静脉点滴,每日1次,共治疗20 d。采用血液动力学分析仪(CBA)对治疗后脑血流速度及脑血管外周阻力进行观察。结果:血管性认知功能障碍患者脑血流速度减慢,脑血管外周阻力增加,葛根素治疗后血液动力学各指标有显著性改善。结论:葛根素对HDS评分的影响有显著性,能显著改善血管性认知功能障碍患者血液动力学指标。
Objective: To observe the influence of puerarin on haemodynamics in vascular cognitive impairment(VCI) patients.Methods: One hundred and twenty VCI patients were randomly divided into two groups(60 patients in each).Patients in treating group were treated with 0.5 g of puerarin and 8.0 g of piracetam intravenously once a day for 20 days,while patients in control group were treated with piracetam only.Cerebral blood flow velocity(Vm) and cerebral peripheral vascular resistance(Rv) were observed with CBA after the treatment.Results: Vm of the patients were slower and Rv of the patients were higher than those of controls,and both Vm and Rv were improved after puerarin were used.Conclutions: Slowed Vm and increased Rv are two important and dangerous factors to VCI patients.Puerarin treatment can improve hemodynamics and scores in HDS assessment.

关键词(KeyWords): 痴呆,血管性;血流动力学;葛根素;血管性认知功能障碍
dementia,vascular;hemodynamics;puerarin;vascular cognitive impairment

Abstract:

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作者(Author): 胡少瑾;李素芳;
HU Shaojin1,LI Sufang2(1.Department of Internal Medicine,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China;2.Department of Neurology,The Third Affiliated Hospital of Xinxiang Medical College,Xinxiang 453003,China)

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DOI: 10.19367/j.cnki.1000-2707.2007.05.010

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