贵州医科大学学报

2013, v.38;No.164(05) 499-501

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乳腺癌中TIP30蛋白的表达及意义
Expression of TIP30 in Breast Carcinoma and Its Significance

李珀;何常;徐恒天;胡斌;刘辉;陆钦丽;
LI Po;HE Chang;XU Hengtian;HU Bin;LIU Hui;LU Qinli;Department of Pathology,the Affiliated Hospital of Guiyang Medical College;Yunyan District Hospital,Guiyang City;

摘要(Abstract):

目的:探讨TIP30蛋白在乳腺癌中的表达及意义。方法:采用免疫组织化学Envision法检测20例乳腺增生症及40例乳腺癌组织中TIP30的表达,分析TIP30在两种组织中表达差异,探讨TIP30的表达与乳腺癌临床分期及病理分级的关系。结果:(1)TIP30在乳腺癌中的阳性表达率明显低于在乳腺增生症组织中的表达率,差异具有统计学意义(P<0.001);(2)TIP30蛋白在乳腺癌组织中的表达与淋巴结转移、临床分期及病理分级有关(P<0.05),与乳腺癌发病年龄无关(P>0.05)。结论:TIP30的表达在乳腺癌的发展、转移及预后中扮演着重要的角色。
Objective: To investigate the expression of tat interacting protein 30(TIP30) in breast carcinoma and to explore its clinical significance.Methods: The expression of TIP30 in 20 specimens of intraductal proliferative lesions and 40 specimens of breast carcinoma was detected with Envision immunohistochemistry method.Results: 1.The positive rate of TIP30 expression was 40%(16 /40) in breast carcinoma,and it was significantly lower than that in intraductal proliferative lesions(95%,19 /20)(P < 0.001).2.The expression of TIP30 in breast carcinoma related to lymph metastasis(P < 0.05),clinical stage(P < 0.05) and pathological gradings(P < 0.05) of the disease,but not related to the ages of patients(P > 0.05).Conclusions: TIP30 expression might play an important role in the development,metastasis,and prognosis of breast carcinoma.

关键词(KeyWords): TIP30;乳腺肿瘤;癌;乳腺增生症;肿瘤分期;免疫组织化学
TIP30,breast neoplasms;carcinoma;intraductal proliferative lesions;neoplasm staging;immunohistochemistry

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作者(Author): 李珀;何常;徐恒天;胡斌;刘辉;陆钦丽;
LI Po;HE Chang;XU Hengtian;HU Bin;LIU Hui;LU Qinli;Department of Pathology,the Affiliated Hospital of Guiyang Medical College;Yunyan District Hospital,Guiyang City;

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DOI: 10.19367/j.cnki.1000-2707.2013.05.016

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