贵州医科大学学报

1991, (04) 305-309

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黄芪抗小鼠及家兔Ⅰ型单纯疱疹病毒的实验研究
Experimental Study of Astragalus Membranaccus against Herpes Simplex Virus Type-1 in the Mice and Rabbits

唐七义;董熙昌;
Tang Qiyi, ct al Department of Microbiology

摘要(Abstract):

本文报道了黄芪、黄芪和无环鸟苷联合在小鼠体内抗Ⅰ型单纯疱疹病毒脑内感染及局部应用黄芪治疗家兔Ⅰ型单纯疱疹性角膜结合膜炎的效果,并和无环鸟苷进行了比较。结果表明黄芪对受10或30LD_(50)Ⅰ型单纯疱疹病毒感染的小鼠均有治疗效果,并证实黄芪有增强无环鸟苷抗Ⅰ型单纯疱疹病毒的作用。局部应用可以控制角膜结合膜病变的发展。但黄芪抗Ⅰ型单纯疱疹病毒的效果不及无环鸟苷。
Astragalus membranaccus (Ast. m) was administered to the mice by gavage immediately after intracerebral inoculation of 10 LD_(50) HSV-1 in mimic treatment group and two days before the inoculation in mimic prophylaxis group. The results showed that in two groups the mortality of the infected mice was reduced and the mean survival days pralonged. The effect of gavage was similar to that of intraperitoneal injection. The effect of combination of Ast. m with acyclovir (ACV) was better than that of ACV or Ast. m alone, which suggested that Ast, m might enhance the efficacy of ACV in treating HSV-1 infection. 200% of Ast. m and 3% of ACV were used in treating HSV-1. kerato-conjunctivitis in rabbits, both Ast. m and ACV could control extension of the inflammation and improve its recovery. ACV was more effective than Ast. m in both animals.

关键词(KeyWords): 人疱疹疯毒;黄芪;无环鸟苷
herpesvirus hominis; Astragalus membranaccus; Acyclovir

Abstract:

Keywords:

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作者(Author): 唐七义;董熙昌;
Tang Qiyi, ct al Department of Microbiology

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DOI: 10.19367/j.cnki.1000-2707.1991.04.006

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