贵州医科大学学报

2008, No.131(02) 165-168

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特发性血小板减少性紫癜患者血小板生成素和β_2-微球蛋白与疗效的关系
An Observation on Relationship of Thrombopoietin and Beta2-microglobulin with the Curative Results of Idiopathic Thrombocytopenic Purpura

苏林冲;戚璐;曾小菁;
SU Linchong,QI lu,ZENG Xiaojing(Department of hematology,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

摘要(Abstract):

目的:探讨特发性血小板减少性紫癜(ITP)患者血清血小板生成素(TPO)和β2-微球蛋白(β2-M)与疗效的关系。方法:初治ITP患者,分为治疗有效组和治疗无效组,设正常对照组20例;采用双抗体夹心酶联免疫吸附法(ELISA)和放射免疫法(RIA),分别检测治疗前后血清TPO和β2-MG。同时检测治疗前骨髓涂片的平均巨核细胞数量。结果:在ITP患者中,治疗无效组的TPO和β2-M则明显高于有效组及对照组(P<0.05),有效组与对照组间无显著差异(P>0.05),而巨核细胞计数则显著低于有效组(P<0.01);治疗后,治疗无效组的β2-M和TPO水平仍明显高于对照组(P<0.05),有效组和无效组治疗后的TPO和β2-M水平略有下降,但差异无统计学意义(P>0.05)。结论:血清高水平TPO和β2-M可能预示ITP治疗困难,表明治疗有效与无效的ITP患者在发病机理方面可能存在差异。
Objective:To investigate the relationship of serum thrombopoietin(TPO),and beta-2mi-croglobulin(β2-M) with the curative results of idiopathic thrombocytopenic purpura(ITP).Methods:Thirty patients with newly diagnosed ITP were divided into effective group(group E,n=23) and ineffective group(group I,n=7),according to their curative results.The serum TPO concentrations of all of the patients and 20 healthy people(as control,group C) were detected by using double-antibody sandwich enzyme-linked immunosorbent assay(ELISA),and the serum β2-M concentrations were detected by using radio-immunoassay(RIA).Bone marrow megakaryocytes were counted before the treatment of ITP.Results:The megakaryocyte counts of patients in group I were significantly lower than that of patients in group E(P<0.01);The TPO and β2-M levels of patients in group I were significantly higher than those of patients in group E and healthy people in group C(P<0.05),and kept significantly higher than those of group C after a period of treatment(P<0.05).The TPO and β2-M levels of the patients in two groups did not change significantly before and after the treatment(P>0.05).Conclusions:High levels of serum TPO and β2-M in ITP patients may be a sign indicating the difficulty in treatment,and there might be some differences in pathogenesis between "effectively cured" and "difficultly-treat" ITP patients.

关键词(KeyWords): 紫癜,血小板减少性,特发性;血小板生成素;β_2-微球蛋白;治疗结果
purpura,thrombocytopenic,idiopathic;thrombopoietin;beta 2-microglobulin;treatment outcome

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作者(Author): 苏林冲;戚璐;曾小菁;
SU Linchong,QI lu,ZENG Xiaojing(Department of hematology,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

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DOI: 10.19367/j.cnki.1000-2707.2008.02.017

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