贵州医科大学学报

2019, v.44;No.222(03) 326-330

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荆花胃康胶丸联合双歧杆菌四联活菌根除幽门螺杆菌对服用抗血小板药物老年患者消化道出血的影响
Effect of Jinghua Weikang Capsules Combined with Bifidobacterium Tetra-active Bacteria on Gastrointestinal Hemorrhage in Elderly Patients with Anti-Platelet Drugs

解淑蕊;李鹏;方文;黄茜;杨湛南;岳亚光;赵慧敏;韩宝娟;李帅;薛敏捷;
XIE Shurui;LI Peng;FANG Wen;HUANG Qian;YANG Zhannan;YUE Yaguang;ZHAO Huimin;HAN Baojuan;LI Shuai;XUE Minjie;Department of Gastroenterology,Xingtai People's Hospital;Department of Physical Examination and Blood Collection,Central Blood Station of Xingtai;School of Laboratory Science,Guizhou Medical University;Department of Cardiology,Xingtai Third Hospital;

摘要(Abstract):

目的:观察荆花胃康胶丸联合双歧杆菌四联活菌根除幽门螺杆菌(HP)感染治疗对服用抗血小板药物老年患者消化道出血的影响。方法:320例60~80岁每日服用100 mg阿司匹林、14C-尿素呼气试验(14CUBT) HP阳性的老年患者均分为联合组(采用荆花胃康胶丸联合双歧杆菌四联活菌片及四联疗法)及单一组(采用四联疗法),分别在治疗前、治疗2周时检测血清白细胞介素-8(IL-8)、IL-10及C反应蛋白(CRP)水平,比较治疗2周时的HP根除率及症状缓解率、记录治疗过程中的不良反应,比较HP阴性组(治疗后成功根除HP患者)和HP阳性组(根除HP治疗失败患者)随访1年的消化道出血发生率。结果:治疗2周时,联合组及单一组患者血清IL-8、IL-10及CRP水平显著低于治疗前(P <0. 05),联合组血清IL-8、IL-10及CRP水平显著低于单一组(P <0. 05);联合组患者HP根除率(91. 25%)高于单一组(79. 38%,P <0. 01),不良反应发生率(16. 25%)低于单一组(31. 88%,P <0. 01),临床症状缓解率(90. 62%)高于单一组(73. 12%,P <0. 01); HP阴性组随访1年的消化道出血发生率(4. 03%)低于HP阳性组(12. 77%,P <0. 05)。结论:荆花胃康胶丸与双歧杆菌四联活菌片联合四联疗法根除HP治疗对服用抗血小板药物、同时有HP感染的老年患者的效果优于单一四联疗法,根除HP感染可以有效降低服用抗血小板药物老年人消化道出血的风险。
Objective: To investigate the effect of Jinghua Weikang capsules combined with Bifidobacterium quadruplet on Digestive tract Hemorrhage in elderly patients with Anti-Platelet drugs and infection of Helicobacter pylori( HP). Methods: 320 60-80-year-old patients with 100 mg aspirin daily and 14 C-urea breath test( 14 C-UBT) HP positive were divided into two groups: combination group( Jinghua Weikang capsules combined with Bifidobacterium quadruplet active bacterial tablets and quadruple therapy) and single group. Serum levels of interleukin-8( IL-8),IL-10 and C-reactive protein( CRP) were measured before treatment and for 2 weeks of treatment. HP eradication rate and symptom remission rate at 2 weeks after treatment were compared. Adverse reactions during treatment were recorded. The incidence of gastrointestinal bleeding was compared between HP-negative group( successful eradication of HP patients after treatment) and HP-positive group( Eradication of failed patients with HP) after 1 year follow-up. Results: After 2 weeks of treatment,the serum levels of IL-8,IL-10 and CRP in the combined group and single group were significantly lower than those before treatment( P < 0. 05). The levels of serum IL-8,IL-10 and CRP in the combined group were significantly lower than those in the single group( P < 0. 05). The HP eradication rate in the combined group( 91. 25%) was higher than that in the single group( 79. 38%,P < 0. 01). The incidence of adverse reactions( 16. 25%) was lower than that of the single group( 31. 88%,P < 0. 01). The clinical symptom remission rate( 90. 62%) was higher than that of single group( 73. 12%,P < 0. 01). The incidence of gastrointestinal bleeding in HP negative group( 4. 03%) was lower than that in HP positive group( 12. 77%,P < 0. 05). Conclusion: The eradication of HP by Jinghua Weikang capsules and Bifidobacterium Tetravaccine tablets combined with quadruple therapy on elderly patients taking antiplatelet drugs can improve the eradication rate of HP and theremission rate of clinical symptom,reduce inflammation and adverse reactions in elderly patients. The eradication of HP therapy can effectively reduce the risk of digestive tract hemorrhage in elderly patients taking anti-platelet drugs.

关键词(KeyWords): 荆花胃康胶丸;双歧杆菌四联活菌片;幽门螺杆菌;消化道出血;抗血小板治疗;老年患者
Jinghua Weikang capsules;bifidobacterium tetravaccine tablets;Helicobacter pylori;digestive tract hemorrhage;antiplatelet therapy;elderly patients

Abstract:

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基金项目(Foundation): 邢台市科技计划项目(2017ZC108);; 国家自然科学基金(81560481)

作者(Author): 解淑蕊;李鹏;方文;黄茜;杨湛南;岳亚光;赵慧敏;韩宝娟;李帅;薛敏捷;
XIE Shurui;LI Peng;FANG Wen;HUANG Qian;YANG Zhannan;YUE Yaguang;ZHAO Huimin;HAN Baojuan;LI Shuai;XUE Minjie;Department of Gastroenterology,Xingtai People's Hospital;Department of Physical Examination and Blood Collection,Central Blood Station of Xingtai;School of Laboratory Science,Guizhou Medical University;Department of Cardiology,Xingtai Third Hospital;

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