贵州医科大学学报

2012, v.37;No.158(05) 483-485

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Chk1在原发性肝癌和肝非肿瘤组织中的表达
Expression of Chk1 in Primary Liver Cancer and Liver Non-tumor Tissue

马瑞波;杨大刚;孙诚谊;王众;
MA Ruibo,YANG Dagang,SUN Chengyi,WANG Zong (Department of Hepatobiliary Surgery,the Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

摘要(Abstract):

目的:探讨细胞周期检测点启动DNA损伤修复的主要激酶Chk1蛋白在肝非肿瘤组织和原发性肝癌组织中的表达差异、以及与临床病理特征之间的关系。方法:应用免疫组织化学法检测15例肝非肿瘤组织(其中正常肝组织7例、肝硬化组织8例)和41例原发性肝癌组织Chk1蛋白的表达。结果:Chk1蛋白在原发性肝癌组织中表达阳性率为73.2%,在肝非肿瘤组织中表达阳性率为26.7%差异有统计学意义(P<0.05);Chk1蛋白在不同分化程度的原发性肝癌患者中的表达有差异,有统计学意义(P<0.05)。结论:Chk1在原发性肝癌中高表达可能与原发性肝癌的发生、发展有关。
Objective: To investigate the expression difference of Chk1 protien in primary liver cancer and non-tumor liver tissue,and to explore the probable relationship between its expression and clinicopathologic features of liver cancer.Methods: Immunohistochemistry was applied to detect the expressions of Chk1 in 15 cases with liver non-tumor tissue(7 cases with normal liver tissue,8 cases with cirrhosis tissue) and 41 cases with primary liver cancer with various differentiation degrees.Results: The positive expression rate of Chk1 in primary liver cancer(73.2%) was higher than that of non-tumor liver tissue(26.7%)(P<0.05).Significant differences were found in Chk1 expressions among primary liver cancer with various differentiation degrees(P<0.05).Conclusions: The high expression level of Chk1 in primary liver cancer indicates that Chk1 may be related to genesis and progression of primary liver cancer.

关键词(KeyWords): 肝肿瘤;癌;细胞周期;免疫组织化学
liver neoplasms;carcinoma;cell cycle;immnohistochemistry

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基金项目(Foundation): 贵州省科技厅基金资助项目(E2008-21)

作者(Author): 马瑞波;杨大刚;孙诚谊;王众;
MA Ruibo,YANG Dagang,SUN Chengyi,WANG Zong (Department of Hepatobiliary Surgery,the Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

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DOI: 10.19367/j.cnki.1000-2707.2012.05.008

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