贵州医科大学学报

2003, (02) 126-128

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酒精中毒患者免疫功能的研究
An Investigation of Immunological Function in Alcoholism Patients

袁平,欧阳杏娟,谈琳,代国祥,罗殿熙
YUAN Ping, OUYANG Xing-Juan , TAN Lin, DAI Guo-xiang, LUO Dian-xi (1. Department of psychiatry, Anning Hospital of Guizhou, Guiyang 550004, China; 2. Department of laboratory, Anning Hospital of Guizhou, Guiyang 550004, China; 3. Department of laboratory, The Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China)

摘要(Abstract):

目的:探讨酒精中毒患者治疗前后部分免疫指标的变化。方法:50例酒精中毒的住院患者和25例正常对照者,采血作T淋巴细胞亚群、自然杀伤细胞(NKC)活性和部分体液免疫物质的测定。结果:酒精中毒患者治疗前 CD_3、CD_4、CD_8、CD_4/CD_8、NKC活性均低于对照组(P<0.01~0.001),而IgA、IgG水平则高于对照组(P<0.001);治疗后CD_3、CD_4、CD_8、CD_4/CD_8、NKC活性高于治疗前(P<0.05~0.01),IgA、IgG水平较治疗前有所降低,与对照组的差异无显著性(P>0.05)。结论:酒精中毒患者存在免疫功能紊乱,提示精神-神经-免疫系统可能存在复杂的相互联系。
Objective: To investigate changes of some immune indices in alcoholism patients before and after treatment. Methods: 50 alcoholism patients and 25 normal people as control were recruited. Subjects were assessed with the criteria of CCMD - 2 - R. Peripheral blood samples were taken for tests of T - cell subsets ( expressed with numbers of CD3, CD4, CD8, and CD4/CD8) , natural killer cell activity(NKCA) ,and humoral immunity. Results: Compared to the controls, the levels of CD3, CD4 , CD8, CD4/CD8, and NKCA were significantly lower in patients before treatment ( P < 0. 001) , while the levels of IgA, IgG was higher (P < 0. 001). After treatment, the levels of CD3, CD4, CD8, CD4/CD8 ,and NKCA significantly increased(P <0. 05 -0. 01) ,and levels of IgA, IgG decreased and there was no significant difference between the patient group and the control group ( P > 0. 05 ) . Conclusion : It is suggested that alcoholic patients may possess immunological dysfunction, and there is a complex interaction between psycho- neuro - immunological systems.

关键词(KeyWords): 酒精中毒;免疫;细胞;免疫球蛋白类;补体
alcoholism; limmunity, cellular; immunoglobulins; complement

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基金项目(Foundation): 贵州省卫生厅基金(94326)

作者(Author): 袁平,欧阳杏娟,谈琳,代国祥,罗殿熙
YUAN Ping, OUYANG Xing-Juan , TAN Lin, DAI Guo-xiang, LUO Dian-xi (1. Department of psychiatry, Anning Hospital of Guizhou, Guiyang 550004, China; 2. Department of laboratory, Anning Hospital of Guizhou, Guiyang 550004, China; 3. Department of laboratory, The Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China)

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