贵州医科大学学报

2009, v.34;No.140(05) 540-541+545

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高碳酸血症对兔急性呼吸窘迫综合征保护作用初探
Experimental Study on the Protective Effects of Hypercapnia to Rabbits with Acute Respiratory Distress Syndrome

黄颖;杜娟;
HUANG Ying,DU Juan(Department of Respiration Internal Medicine,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

摘要(Abstract):

目的:通过观察肺组织病理学变化,探讨高碳酸血症对兔急性呼吸窘迫综合征(ARDS)的保护作用。方法:建立兔急性呼吸窘迫综合征动物模型并连接动物呼吸机,将兔随机分为两组,实验组给予外源性CO2吸入(浓度为6%),实验对照组不给予外源性CO2吸入。分别观察2组兔肺组织湿重与干重比值及肺组织形态学变化。结果:(1)实验组兔的肺部水肿与炎性细胞浸润较对照组减轻,肺组织湿重与干重比值高于对照组;(2)两组可见广泛的灶性肺不张及肺成纤维细胞增生。结论:(1)高碳酸血症可减轻肺局部炎症,对兔急性呼吸窘迫综合征产生保护作用;(2)偏小的潮气量仍易导致ARDS兔广泛的灶性肺不张;(3)ARDS兔早期即可见到肺成纤维细胞增生。
Objective:To investigate the protective effect of hypercapnia on rabbits with acute respiratory distress syndrome (ARDS) by using histopathological methods. Methods: ARDS Rabbit models were established and connected with animal ventilator,and mechanical ventilation was provided after tracheotomy. The ventilator parameters were: tidal volume 8ml/kg,R 51/min,PEEP 5 cmHO2,and FiO2 0.60. Rabbits were randomly divided into two groups,and those in experimental group were given CO2(FiCO2 0.06)while those in control group were not. The wet/dry weigh ratio and morphological change of lung tissue were observed and compared between the two groups in 180 minutes. Result: (1)Lung tissue edema and inflammatory cell infiltration were milder and lung tissue wet/dry weigh ratio was higher in experimental group than those in control group;(2)Extensive focal atelectasis and pulmonary interstitial fibrosis were found in both groups;Conclusion: (1)Hypercapnia can lighten lung parts and systemic inflammatory injury,and protect ARDS rabbits;(2) Too small tide volume can cause atelectasis in ARDS rabbits;(3)Pulmonary interstitial fibrosis can be found in the early period of ARDS.

关键词(KeyWords): 高碳酸血;呼吸窘迫综合征;肺;病理学
hypercapnia;respiratory distress syndrome;lung;pathology

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 黄颖;杜娟;
HUANG Ying,DU Juan(Department of Respiration Internal Medicine,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

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DOI: 10.19367/j.cnki.1000-2707.2009.05.018

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