盛玉山;林冬梅;
SHENG Yushan;LIN Dongmei;Pharmacy Department,Jinzhou Corning Hospital;Depression Zone,Jilin Provincial Neuropsychiatric Hospital;

• 1:锦州市康宁医院药剂科
• 2:吉林省神经精神病医院抑郁专病疗区

摘要(Abstract)：

目的:探讨首发精神分裂症患者血清细胞因子水平与阳性和阴性症状量表(PANSS)评分的。方法:45例首发精神分裂症患者作为观察组,根据PANSS评分分为71~80分组、81~90分组及91~97分组,另选20例健康体检者作为对照组,利用酶联免疫吸附试验法(ELISA)测定对两组受试者血清白细胞介素1α(IL-1α)、IL-1β、IL-6、IL-7及肿瘤坏死因子(TNF-α)水平;比较观察组不同PANSS分值患者与对照组被检者的血清IL-1α、IL-1β、IL-6、IL-7及TNF-α水平,采用Pearson检验分析这些细胞因子与首发精神分裂症患者精神症状严重程度的相关性。结果:与对照组比较,观察组患者血清IL-1α、IL-1β、IL-7及TNF-α水平显著较高(P<0.05),血清IL-6水平变化不大(P>0.05);随着PANSS评分增加,患者血清IL-1α、IL-1β、IL-7及TNF-α水平升高,但仅91~97分组与71~80分组比较,差异统计学意义(P<0.05);Pearson检验分析结果显示,血清IL-1α、IL-1β、IL-7、TNF-α水平患者精神症状严重程度呈显著正相关(r=0.56、0.58、0.59、0.70,P<0.05),IL-6无显著相关(r=0.19,P>0.05)。结论:首发精神分裂症患者处于免疫激活的状态,其激活程度与患者精神症状严重程度相关。
Objective: To study the relationship between serum cytokine levels and clinical features in patients with first-episode schizophrenia. Methods: 45 patients with first episode schizophrenia were selected as the observation group. 20 healthy volunteers who received physical examination were selected as the control group. The interleukin 1α( IL-1α),interleukin 1β( IL-1β),interleukin-6( IL-6),interleukin-7( IL-7),tumor necrosis factor α( TNF-α) levels were measured by enzymelinked immunosorbent assay,and the psychiatric symptoms of the two groups were assessed by positive and negative status scale( PANSS). Pearson analysis was employed to detect the correlation between serum cytokine levels and clinical features. Results: The levels of serum IL-1α,IL-1β,IL-7 and TNF-α were significantly higher in the observation group than in the control group( P < 0. 05),but the difference of serum IL-6 was not significant( P > 0. 05). With the increase of PANSS score,serum IL-1α,IL-1β,IL-7 and TNF-α levels elevated,but only in 91 ~ 97 score group and 71 ~ 80 score group,the difference was statistically significant( P < 0. 05); Pearson analysis showed that IL-1α,IL-1β,IL-7 and TNF-α were positively related to mental symptom severity( r = 0. 56,0. 58,0. 59,0. 70,P <0. 05),no significant correlation was found between the IL-6 and mental symptom severity( r = 0. 19,P > 0. 05). Conclusion: Patients with first episode schizophrenia are in an immune-activated state,and their activation is closely related to mental symptom severity.

关键词(KeyWords)： 精神分裂症;发作,首次;细胞因子;白细胞介素;肿瘤坏死因子;阳性和阴性状态量表
schizophrenia;episode,first;cytokines;interleukin;tumor necrosis factor;positive and negative state scale

Abstract:

Keywords:

基金项目(Foundation): 吉林省卫生计生科研计划(20152105)

作者(Author): 盛玉山;林冬梅;
SHENG Yushan;LIN Dongmei;Pharmacy Department,Jinzhou Corning Hospital;Depression Zone,Jilin Provincial Neuropsychiatric Hospital;

Email:

DOI: 10.19367/j.cnki.1000-2707.2018.01.020

参考文献(References)：

• [1]LV M H,TAN Y L,YAN S X,et al.Decreased serum TNF-alpha levels in chronic schizophrenia patients on long-term antipsychotics:correlation with psychopathology and cognition[J].Psychopharmacology,2015,232(1):165-172.
• [2]ZHU Q,LI X,HIE G,et al.Analysis of the changes of serum high mobility group protein B1 and cytokines in firstepisode schizophrenia patients[J].Zhonghua Yi Xue Za Zhi,2016,95(1):3818-3825.
• [3]田甜,王丽莉,王从辉,等.未系统服药精神分裂症患者血清碱性成纤维细胞生长因子、血管内皮细胞生长因子和基质金属蛋白酶-9的分析[J].中国慢性病预防与控制,2015,23(2):130-132.
• [4]陈传刚,王静,尹晓煜,等.精神分裂症患者血清细胞因子水平变化及其与病情的关系[J].山东医药,2016,56(8):89-90.
• [5]STUBBS B,WANG A K,VANCAMPFORT D,et al.Are leptin levels increased among people with schizophrenia versus controls?A systematic review and comparative meta-analysis.[J].Psychoneuroendocrinology,2015,63:144-154.
• [6]梁锋,杨远坚,熊建文,等.精神分裂症血清胰岛素样生长因子2与临床特征的关系[J].中国神经精神疾病杂志,2015,41(7):401-405.
• [7]杨淑珍,赵晶媛,宋学勤.氯氮平治疗女性精神分裂症患者血药浓度与细胞因子的相关性分析[J].重庆医学,2015,44(24):3399-3401.
• [8]程伟.奥氮平联合无抽搐电休克治疗对精神分裂症患者细胞因子、s TNFRs及神经电生理特征的影响[J].海南医学院学报,2016,22(23):2893-2896.
• [9]LASKARIS L,CROPLEY V,LIBERG B,et al.Higher peripheral cytokines are associated with smaller left hippocampal volume:a relationship confined to schizophrenia patients[C].Australasiam Schizophrenia Conference,2015,26(21):289-296.
• [10]黄满丽,陈京凯,叶于富,等.首发精神分裂症患者调节性T细胞及相关细胞因子变化[J].浙江医学,2015,37(14):1189-1192.
• [11]O'CONNELL K E,THAKORE J,DEV K K.Increased interleukin 23(IL23)levels in schizophrenia patients treated with depot antipsychotic medication.[J].Cytokine,2015,73(1):196-198.
• [12]陈立勇,陈重,李雪晶.精神分裂症伴代谢综合征患者血清细胞因子含量测定及与神经电生理的相关性分析[J].海南医学院学报,2016,22(13):1422-1425.
• [13]SCHWIELER L,LARSSON M K,SKOGH E,et al.Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia—significance for activation of the kynurenine pathway.[J].Journal of Psychiatry&Neuroscience Jpn,2015,39(6):140-145.
• [14]ZHANG X Y,TAN Y L,CHEN D C,et al.Serum IL-18level,clinical symptoms and IL-18-607A/C polymorphism among chronic patients with schizophrenia in a Chinese Han population.[J].Psychoneuroendocrinology,2016,68(12):140-151.
• [15]朱琦玥,李雪,黑钢瑞,等.首发精神分裂症患者血清中高迁移率族蛋白B1及细胞因子的变化分析[J].中华医学杂志,2015,95(47):3818-3822.
• [16]毕斌,何军,罗洁,等.血清IL-6、IL-18及TNF-α水平对抑郁症首次发作的诊断价值[J].贵阳医学院学报,2016,41(5):546-550.
• [17]马骏,孙梦夕,张琳,等.首发精神分裂症患者治疗效果与血清炎性因子水平变化关系研究[J].新乡医学院学报,2017,34(2):113-116.
• [18]龙义国,官志忠.精神分裂症患者大脑皮质尼古丁受体亚单位蛋白质水平的改变[J].贵阳医学院学报,2002,27(4):283-286.
• [19]颜涛,程超,王会霞,等.血清IL-6、TNF-α和IL-1β在首发精神分裂症患者中的检测及意义[J].海南医学院学报,2015,21(8):1106-1108.

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