贵州医科大学学报

2018, v.43;No.208(01) 88-91

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首发精神分裂症患者血清白细胞介素和肿瘤坏死因子水平变化
The Changes of Serum Interluekin and Tumor Necrosis Factor Levels in Patients with First Episode Schizophrenia

盛玉山;林冬梅;
SHENG Yushan;LIN Dongmei;Pharmacy Department,Jinzhou Corning Hospital;Depression Zone,Jilin Provincial Neuropsychiatric Hospital;

摘要(Abstract):

目的:探讨首发精神分裂症患者血清细胞因子水平与阳性和阴性症状量表(PANSS)评分的。方法:45例首发精神分裂症患者作为观察组,根据PANSS评分分为71~80分组、81~90分组及91~97分组,另选20例健康体检者作为对照组,利用酶联免疫吸附试验法(ELISA)测定对两组受试者血清白细胞介素1α(IL-1α)、IL-1β、IL-6、IL-7及肿瘤坏死因子(TNF-α)水平;比较观察组不同PANSS分值患者与对照组被检者的血清IL-1α、IL-1β、IL-6、IL-7及TNF-α水平,采用Pearson检验分析这些细胞因子与首发精神分裂症患者精神症状严重程度的相关性。结果:与对照组比较,观察组患者血清IL-1α、IL-1β、IL-7及TNF-α水平显著较高(P<0.05),血清IL-6水平变化不大(P>0.05);随着PANSS评分增加,患者血清IL-1α、IL-1β、IL-7及TNF-α水平升高,但仅91~97分组与71~80分组比较,差异统计学意义(P<0.05);Pearson检验分析结果显示,血清IL-1α、IL-1β、IL-7、TNF-α水平患者精神症状严重程度呈显著正相关(r=0.56、0.58、0.59、0.70,P<0.05),IL-6无显著相关(r=0.19,P>0.05)。结论:首发精神分裂症患者处于免疫激活的状态,其激活程度与患者精神症状严重程度相关。
Objective: To study the relationship between serum cytokine levels and clinical features in patients with first-episode schizophrenia. Methods: 45 patients with first episode schizophrenia were selected as the observation group. 20 healthy volunteers who received physical examination were selected as the control group. The interleukin 1α( IL-1α),interleukin 1β( IL-1β),interleukin-6( IL-6),interleukin-7( IL-7),tumor necrosis factor α( TNF-α) levels were measured by enzymelinked immunosorbent assay,and the psychiatric symptoms of the two groups were assessed by positive and negative status scale( PANSS). Pearson analysis was employed to detect the correlation between serum cytokine levels and clinical features. Results: The levels of serum IL-1α,IL-1β,IL-7 and TNF-α were significantly higher in the observation group than in the control group( P < 0. 05),but the difference of serum IL-6 was not significant( P > 0. 05). With the increase of PANSS score,serum IL-1α,IL-1β,IL-7 and TNF-α levels elevated,but only in 91 ~ 97 score group and 71 ~ 80 score group,the difference was statistically significant( P < 0. 05); Pearson analysis showed that IL-1α,IL-1β,IL-7 and TNF-α were positively related to mental symptom severity( r = 0. 56,0. 58,0. 59,0. 70,P <0. 05),no significant correlation was found between the IL-6 and mental symptom severity( r = 0. 19,P > 0. 05). Conclusion: Patients with first episode schizophrenia are in an immune-activated state,and their activation is closely related to mental symptom severity.

关键词(KeyWords): 精神分裂症;发作,首次;细胞因子;白细胞介素;肿瘤坏死因子;阳性和阴性状态量表
schizophrenia;episode,first;cytokines;interleukin;tumor necrosis factor;positive and negative state scale

Abstract:

Keywords:

基金项目(Foundation): 吉林省卫生计生科研计划(20152105)

作者(Author): 盛玉山;林冬梅;
SHENG Yushan;LIN Dongmei;Pharmacy Department,Jinzhou Corning Hospital;Depression Zone,Jilin Provincial Neuropsychiatric Hospital;

Email:

DOI: 10.19367/j.cnki.1000-2707.2018.01.020

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