贵州医科大学学报

1993, (03) 161-164

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地方性克汀病病区加碘盐11年后胎儿大脑M—胆碱受体的研究
Studies on the Cerebral Muscarinic Receptors of the Fetuses from an Endemic Cretinism Region after Eleven Years Supplement of Iodized Salt

卢步峰;万昌武;董仲;黄诒森;刘家骝;
Lu Bufeng,et al Zhenjiang Medical College

摘要(Abstract):

报告12例非病区和6例地方性克汀病病区加碘盐11年后人工引产胎儿大脑M-胆碱受体的研究。结果显示,与非病区相比,病区胎儿大脑M—胆碱受体密度(Bmax)显著降低(P<0.05),而配基-受体解离常数(Kd)则明显升高(P<0.01),表明病区补碘后胎儿发育过程中,大脑M-胆碱受体发育存在显著的迟滞现象,这可能是病区仍然有亚克汀病病例存在的分子基础。
In order to provide further evidences for the epidemiologic and morphologic findings on endemic cretinism,we studied the cerebral muscarinic receptors of therapeutically aborted fetuses from an endemic cretinism region after supplement of iodized salt for elven years with radioligand assay. The results showed that the density(Bmax) of the cerebral muscarinic receptors in the fetuses from the endemic region(168.25±31.99 fmol·mgPr~(-1),n=6)was significantly lower as compared witn the fetuses from the non-endemic region(235.71±65.19 fmol·mgPr~(-1), n=12)(P<0.05), whereas the ligand-receptor dissociation constant(Kd)in the endemic group(l.811±0.525 nmol·L~(-1)) was markedly higher than that in the non-endemic group(0.286±0.062nmol·L~(-1))(P<0.01).These suggest that the development of the cerebral muscarinic receptors in the fetuses from the endemic region after suppleme nt of iodized salt was still retarded.

关键词(KeyWords): 胎儿;大脑;克汀病;M-胆碱受体
fetus;brain;cretinism;muscarinic receptor

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基金项目(Foundation): 卫生部资助项目

作者(Author): 卢步峰;万昌武;董仲;黄诒森;刘家骝;
Lu Bufeng,et al Zhenjiang Medical College

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